Stem Cell-Derived Human Tissue Models for the Identification of Drugs to Treat COVID-19

Ancestral, Delta, and Omicron (BA.1) SARS-CoV-2 strains are dependent on serine proteases for entry throughout the human respiratory tract

MJ Gartner, LYY Lee, FL Mordant, R Suryadinata, J Chen, P Robinson, JM Polo, K Subbarao

2023-12-08

Background: The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and became the globally dominant variant by January 2022. Aut..

A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts

J Chen, JA Neil, JP Tan, R Rudraraju, M Mohenska, YBY Sun, E Walters, NG Bediaga, G Sun, Y Zhou, Y Li, D Drew, P Pymm, WH Tham, FJ Rossello, G Nie, X Liu, K Subbarao, JM Polo

2023-08-01

SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes an..

Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment

R Rudraraju, MJ Gartner, JA Neil, ES Stout, J Chen, EJ Needham, M See, C Mackenzie-Kludas, LY Yang Lee, M Wang, H Pointer, K Karavendzas, D Abu-Bonsrah, D Drew, YB Yang Sun, JP Tan, G Sun, A Salavaty, N Charitakis, HT Nim

2023-06-13

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the respiratory tract, but pulmonary and cardiac co..

ACE2 Expression in Organotypic Human Airway Epithelial Cultures and Airway Biopsies

Q Chen, S Langenbach, M Li, YC Xia, X Gao, MJ Gartner, EA Pharo, SM Williams, S Todd, N Clarke, S Ranganathan, ML Baker, K Subbarao, AG Stewart

2022-03-11

Coronavirus disease 2019 (COVID-19) caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a..

Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models

KH Benam, JK Burgess, AG Stewart

2022-01-03